From A Tale of Two Sons by John Macarthur, page 78:
When we sin, we show disdain for God’s fatherly love as well as His holy authority. We spurn not merely His law, but also His very person. To sin is to deny God His place. It is an expression of hatred against God. It is tantamount to wishing He were dead. It is dishonoring to Him. And since all sin has at its heart this element of contempt for God, even the smallest sin has enough evil to unleash an eternity full of mischief, misfortune, and misery. The fact that the entire world of human evil all stemmed from Adam’s simple act of disobedience is vivid proof of that (Romans 5:12, 19; 1 Corinthians 15.21-22).”